Management of Hepatitis B Infection

  • Authors: Harry L. A. Janssen, MD, PhD; Milan J. Sonneveld, MD, PhD, MSc (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 5/25/18 (What's New)


  • International guidelines recommend chronic HBV–infected patients with advanced liver disease and cirrhosis receive anti-HBV treatment, as this group is at increased risk of hepatocellular carcinoma and death[Terrault 2018; EASL HBV]
  • Hepatocellular carcinoma risk is still considerable after 5 years of treatment in patients with decompensated cirrhosis[Arends 2015; Lim 2014]
  • Peginterferon
    • Peginterferon treatment can be effective in patients with advanced fibrosis and compensated cirrhosis but is contraindicated in patients with decompensated liver disease
          Tenofovir DF

          Action required