Management of Hepatitis B Infection

  • Authors: Harry L. A. Janssen, MD, PhD; Milan J. Sonneveld, MD, PhD, MSc (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 5/25/18 (What's New)


  • Adefovir has been extensively used in patients with advanced liver disease, with low rates of resistance (2% at 144 weeks of follow-up)[Schiff 2007]
  • Adefovir is generally safe in this population, despite the risk of nephrotoxicity,[Zoulim 2008] which may be a particular concern in patients with decompensated cirrhosis

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