Management of Hepatitis B Infection

  • Authors: Harry L. A. Janssen, MD, PhD; Milan J. Sonneveld, MD, PhD, MSc (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 5/25/18 (What's New)


  • Long-term tenofovir therapy through 5 years has been shown to reduce fibrosis and may reverse cirrhosis in some patients[Marcellin 2013]
  • Tenofovir, alone or in combination with emtricitabine, results in potent viral suppression in patients with decompensated liver disease and has a similar safety profile to entecavir[Liaw 2011b]
  • The risk of nephrotoxicity with tenofovir is unknown but may be a greater concern in patients with decompensated liver disease[Fontana 2009]

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