Management of Hepatitis B Infection

  • Authors: Harry L. A. Janssen, MD, PhD; Milan J. Sonneveld, MD, PhD, MSc (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 5/25/18 (What's New)


  • International guidelines recommend 3-4 HBV agents as “preferred” options in first-line therapy: peginterferon, entecavir, tenofovir DF, and tenofovir AF[Terrault 2018; EASL HBV; APASL HBV]
    • Nucleos(t)ide analogues are the most frequently used first-line treatment options
  • Treatment selection should be individualized according to the needs of the patient (Table 6 and Table 7)
  • Baseline Predictors of Response to Peginterferon Therapy
      Hepatitis B e Antigen–Positive Patients
        Hepatitis B e Antigen–Negative Patients

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