Management of Hepatitis B Infection

  • Authors: Harry L. A. Janssen, MD, PhD; Milan J. Sonneveld, MD, PhD, MSc (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 5/25/18 (What's New)


  • Peginterferon should be offered to patients with the highest probability of response (Table 8)
  • Hepatitis B e Antigen–Positive Patients
    • Baseline factors associated with an increased likelihood of response to peginterferon in HBeAg-positive patients include HBV genotype, older age, female sex, higher serum ALT levels, and lower serum HBV DNA levels (Table 8)[Erhardt 2005; Wai 2002; Buster 2009]
    Hepatitis B e Antigen–Negative Patients
    • Baseline predictors of response to peginterferon in HBeAg-negative patients include female sex, HBV genotype, higher baseline ALT level, and lower baseline HBV DNA levels[Bonino 2007]

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