Management of Hepatitis B Infection

  • Authors: Harry L. A. Janssen, MD, PhD; Milan J. Sonneveld, MD, PhD, MSc (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 5/25/18 (What's New)


  • Peginterferon is typically administered for 1 year, after which therapy is discontinued (Table 9)
    • Some patients achieve an off-treatment sustained response (assessed at 6 months posttreatment) and require no further therapy
      • In patients with HBeAg-positive disease, this is defined as an off-treatment sustained loss of HBeAg with appearance of anti-HBe (HBeAg seroconversion)

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