Hepatitis B Management in Special Populations
Summary
- Treatment in the third trimester of pregnancy may lower risk of perinatal HBV transmission
- Maternal viremia plays a significant role in perinatal transmission. Studies have reported increased risk of transmission with high levels of viremia (> 8 log10 copies/mL or ~ 7.3 log10 IU/mL)[Burk 1994; Xu 2009; van Zonneveld 2003]
- AASLD guidance panel suggests antiviral therapy during third trimester to decrease risk of HBV perinatal transmission in HBsAg-positive pregnant women with HBV DNA > 200,000 IU/mL[AASLD HBV]
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