Hepatitis B Management in Special Populations

  • Author: Alessandra Mangia, MD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 6/4/18 (What's New)

Summary

Introduction

  • Newer therapies for hepatitis B have increased viral suppression rates and reduced rates of viral resistance following treatment
  • Management of hepatitis B in populations with complex needs may require novel strategies

Hepatitis B Virus Coinfection: HIV and Hepatitis C and D Viruses

    Hepatitis B Virus and HIV Coinfection
    • An estimated 5% to 10% of global HBV infections are in HIV-coinfected patients
    • Hepatitis B is generally more aggressive in patients coinfected with HIV, with higher rates of chronicity, higher HBV DNA levels, more frequent reactivation periods, and more rapid progression to cirrhosis[Puoti 2006]
    • HBV causes significant liver-related mortality in HIV-infected patients[Weber 2006; Thio 2002]
    • HBV/HIV-coinfected patients may exhibit abnormal liver tests for multiple reasons, including medication use, steatosis, or coinfections[...

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