Hepatitis C Virus Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Francesco Negro, MD (More Info)
  • Editors In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 5/23/18 (What's New)


  • HCV is a major bloodborne human pathogen affecting approximately 1% of the global population[WHO 2017]
  • The most important route of transmission in developed countries is injection drug use
  • If untreated, most acute infections progress to chronic infection and liver disease
  • Progression to advanced liver disease and HCC is influenced by several cofactors, the most important being alcohol abuse and metabolic syndrome[Alberti 2009]
  • Aging of the currently infected population is expected to result in significant increases in the incidence of HCV-related cirrhosis and HCC

The hepatitis C virus (HCV) is a major bloodborne human pathogen with a current global prevalence rate of approximately 1%, and 71 million individuals have chronic HCV infection.[WHO 2017]...

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Keywords: Hepatitis C