Hepatitis C Virus Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Francesco Negro, MD (More Info)
  • Editors In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 5/23/18 (What's New)


  • The rate of HCV transmission from mother to child is 4.3% among women who are HCV RNA positive, increasing to 22.1% when the mother is coinfected with HIV[Yeung 2001]
  • Due to the passive transfer of anti-HCV antibodies, a firm diagnosis of perinatal transmission should be based on 2 subsequent determinations of serum HCV RNA and/or anti-HCV positivity in infants at or beyond 18 months of age[EPHN 2005]
    • Testing for HCV RNA at 6 months of age and again at 1 year has been suggested to avoid false-negative results[Polywka 2006]

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