Hepatitis C Virus Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Francesco Negro, MD (More Info)
  • Editors In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 10/30/20 (What's New)


  • HCV-associated cell damage seems to be largely mediated by the host immune response
    • The hallmark of liver damage associated with HCV infection is a lympho-mononuclear infiltrate mostly represented by CD8+ T cells that are thought to play a major role in viral containment
    • Intrahepatic CD4+ and CD8+ cells are specific for different structural and nonstructural HCV antigens[Koziel 1992; Schirren 2000]

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