Hepatitis C Virus Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Francesco Negro, MD (More Info)
  • Editors In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 10/30/20 (What's New)


  • HCV infection is associated with steatosis and requires lipids for replication and virion assembly; moreover, the host serum lipid profile is modified by HCV
  • Direct involvement of HCV is supported by several observations[Poynard 2003]
    • Steatosis is more frequent and severe in patients with genotype 3 HCV

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