Hepatitis C Virus Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Francesco Negro, MD (More Info)
  • Editors In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 5/23/18 (What's New)


    • Current CDC (Management Guidelines),[CDC Chronic HCV]  US Preventive Services Task Force (Management Guidelines),[USPSTF Screening] and AASLD-IDSA guidelines (Management Guidelines)[AASLD-IDSA HCV] recommend that all adults born between 1945 and 1965 receive 1-time testing for HCV infection without previous ascertainment of HCV risk
      • Click here to view a Video Insight in which John W. Ward, MD, discusses the background to the updated birth cohort screening guidance from the CDC
    • Anti-HCV screening in other populations should be based on risk assessment, with 1-time HCV testing recommended for all individuals with the following behaviors, conditions, or exposures associated with elevated risk of HCV infection[AASLD-IDSA HCV]:
      Video Insight: The CDC’s Guidance on 1-Time HCV Testing for Baby Boomers
        Serologic Assays
          Molecular Tests (Hepatitis C Virus RNA Quantification and Genotyping)
            The Role of Liver Histology

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