Hepatitis C Virus Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Francesco Negro, MD (More Info)
  • Editors In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 10/30/20 (What's New)


  • The natural history of HCV infection begins with a generally unrecognized acute phase occurring during the initial 6 months following exposure to HCV
  • Acute infection may resolve spontaneously, but the majority of cases progresses to chronic infection
  • Primary Infection and Acute Hepatitis C
    • Primary infection with HCV is mostly asymptomatic and some patients may delay seeking medical consultation
      Chronic Hepatitis C

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