- HCV is a major bloodborne human pathogen affecting approximately 1% of the global population[WHO 2017]
- The most important route of transmission in developed countries is injection drug use
- If untreated, most acute infections progress to chronic infection and liver disease
- Progression to advanced liver disease and HCC is influenced by several cofactors, the most important being alcohol abuse and metabolic syndrome[Alberti 2009]
- Aging of the currently infected population is expected to result in significant increases in the incidence of HCV-related cirrhosis and HCC
Epidemiology of Hepatitis C Virus
Overview of Global Epidemiology
- Prevalence rates of HCV in very low endemicity countries vary greatly from those in highly endemic areas where rates of infection are as high as 10% (Figure 1)[...