HCV is a major bloodborne human pathogen affecting approximately 1% of the global population[WHO 2017]
The most important route of transmission in developed countries is injection drug use
If untreated, most acute infections progress to chronic infection and liver disease
Progression to advanced liver disease and HCC is influenced by several cofactors, the most important being alcohol abuse and metabolic syndrome[Alberti 2009]
Aging of the currently infected population is expected to result in significant increases in the incidence of HCV-related cirrhosis and HCC
Epidemiology of Hepatitis C Virus
Overview of Global Epidemiology
Prevalence rates of HCV in very low endemicity countries vary greatly from those in highly endemic areas where rates of infection are as high as 10% (Figure 1)[...
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