Management of Hepatitis C Infection

  • Authors: Jordan J. Feld, MD, MPH; Hemant Shah, MD, MScCH HPTE (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/24/18 (What's New)

Summary

  • Viral NS3/NS4A serine protease is essential for HCV replication and evasion of immune responses[Scheel 2013; Horner 2013]
  • 4 NS3/NS4A protease inhibitors approved, marketed, and in common use in the United States and European Union include glecaprevir, grazoprevir, and voxilaprevir
  • Grazoprevir
    • Grazoprevir is an NS3/NS4A serine protease inhibitor
    Voxilaprevir
      Glecaprevir

      Action required