Management of Hepatitis C Infection

  • Authors: Jordan J. Feld, MD, MPH; Hemant Shah, MD, MScCH HPTE (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/24/18 (What's New)


  • NS5B is sole RNA polymerase responsible for HCV replication
  • Sofosbuvir currently only NS5B nucleotide analogue inhibitor approved in the United States and elsewhere
  • Sofosbuvir has pangenotypic activity and a high barrier to resistance

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