Management of Hepatitis C Infection

  • Authors: Jordan J. Feld, MD, MPH; Hemant Shah, MD, MScCH HPTE (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/24/18 (What's New)


  • Treatment-naive patients with compensated cirrhosis should be treated in the same manner as patients without cirrhosis, although regimens and treatment duration differ (Management Guidelines)[AASLD-IDSA HCV]
  • Antiviral treatment in patients with cirrhosis is associated with increased risk of complications and lower rates of SVR when compared with patients without cirrhosis using peginterferon-containing regimens[Iacobellis 2007]
  • Combination therapy with ledipasvir/sofosbuvir, daclatasvir plus sofosbuvir, or sofosbuvir/velpatasvir may be considered in patients with compensated cirrhosis awaiting liver transplantation or those with recurrent HCV after liver transplantation[AASLD-IDSA HCV]

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