Management of Hepatitis C Infection

  • Authors: Jordan J. Feld, MD, MPH; Hemant Shah, MD, MScCH HPTE (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/24/18 (What's New)

Summary

  • Efficacy of HCV treatment varies by HCV genotype and fibrosis stage
  • Some newer DAAs have activity against multiple or all genotypes
  • Ledipasvir/Sofosbuvir
    • All 3 phase III ION trials demonstrated high SVR rates with  ledipasvir/sofosbuvir with or without ribavirin when administrated for 8, 12, or 24 weeks in patients with genotype 1 HCV infection
      Sofosbuvir/Velpatasvir
        Sofosbuvir/Velpatasvir/Voxilaprevir
          Elbasvir/Grazoprevir
            Glecaprevir/Pibrentasvir
              Direct-Acting Antivirals in Cirrhotic Patients
                Ledipasvir/Sofosbuvir
                  Sofosbuvir/Velpatasvir
                    Sofosbuvir/Velpatasvir/Voxilaprevir
                      Elbasvir/Grazoprevir
                        Glecaprevir/Pibrentasvir

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