Management of Hepatitis C Infection

  • Authors: Jordan J. Feld, MD, MPH; Hemant Shah, MD, MScCH HPTE (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/24/18 (What's New)


  • Responses to approved interferon-based therapies are greatest with genotype 2, followed by genotype 3, genotype 4, and then genotype 1
  • High baseline HCV RNA is associated with poorer response to interferon-based therapies
  • Subgenotype 1a has lower barrier to resistance to protease and NS5A inhibitors than subgenotype 1b[Halfon 2011]

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