Management of Hepatitis C Infection

  • Authors: Jordan J. Feld, MD, MPH; Hemant Shah, MD, MScCH HPTE (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/24/18 (What's New)


  • Advanced fibrosis/cirrhosis is associated with reduced likelihood of SVR, including to DAA therapy
  • IL28B genotype is associated with interferon responsiveness and SVR to interferon-based therapy[Ge 2009; Tanaka 2009; Thomas 2009]
  • Higher IP-10 serum levels, higher BMI, and/or presence of insulin resistance are associated with treatment nonresponse in patients receiving interferon-based therapy[Lagging 2006; Diago 2006; Romero 2006]

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