Management of Hepatitis C Infection

  • Authors: Jordan J. Feld, MD, MPH; Hemant Shah, MD, MScCH HPTE (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/24/18 (What's New)

Management of Hepatitis C Infection


  • Virologic cure is a realistic goal for most patients with HCV in settings where new direct-acting antivirals are available

Goals of Therapy

  • Goal of HCV therapy is virologic cure defined as SVR after HCV therapy is discontinued
  • SVR associated with decreases in all-cause mortality, liver-related death, liver-related complications, need for liver transplantation, and incidence of hepatocellular cancer[Morgan 2010; Veldt 2007]
    • Patients with history of advanced fibrosis/cirrhosis remain at increased risk of liver cancer even after SVR, requiring ongoing monitoring[Shiffman 2009]

Types of Therapy