- HCV is a major cause of cirrhosis and hepatocellular carcinoma worldwide[Ponziani 2011]
- In the US, HCV is a leading cause of liver-related death and the most common indication for liver transplantation[Fayek 2016; CDC HCV FAQ]
- Effective HCV therapies are available; the presence of comorbidities, coinfections, and other special patient circumstances may complicate their use in clinical practice
Persons Who Inject Drugs
Transmission and Prevalence
- HCV transmission is most efficient through percutaneous exposure to contaminated blood, which is often present in needles and drug preparation materials shared among PWID[Zibbell 2015; ...