Hepatitis C Virus Epidemiology, Pathogenesis, Diagnosis, and Natural History
Summary
- Chronic HCV infection is a progressive disease, taking decades to reach the final stage of cirrhosis, which may evolve toward liver failure or HCC (~ 2% to 4% yearly) (Figure 5)
- The most important factor influencing liver disease progression is the extent of intrahepatic inflammation elicited by HCV (Table 10)[Leandro 2006]
- Patients with persistently normal ALT exhibit slow liver disease progression[Mathurin 1998]
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