Hepatitis C Virus Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Francesco Negro, MD (More Info)
  • Editors In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 10/30/20 (What's New)


    • Current US Preventive Services Task Force (Management Guidelines),[USPSTF Screening] and AASLD-IDSA guidelines (Management Guidelines)[AASLD-IDSA HCV] recommend that all individuals aged 18 years or older receive one-time, routine, opt-out testing for HCV infection without previous ascertainment of HCV risk
    • Anti-HCV screening in persons younger than 18 years of age should be based on risk assessment, with one-time HCV testing recommended for all individuals with the following behaviors, conditions, or exposures associated with elevated risk of HCV infection[AASLD-IDSA HCV]:
      • History of or current illicit injection drug use
    Serologic Assays
      Molecular Tests (Hepatitis C Virus RNA Quantification and Genotyping)
        The Role of Liver Histology

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