Hepatitis C Virus Epidemiology, Pathogenesis, Diagnosis, and Natural History
Summary
- The AASLD and IDSA guidelines recommend that all patients with HCV infection be evaluated for the presence of advanced fibrosis using either liver biopsy, imaging techniques, or noninvasive biomarkers (Management Guidelines)[AASLD-IDSA HCV]
- EASL guidelines recommend that fibrosis stage be initially determined by well-established noninvasive techniques, or by liver biopsy in cases with known or suspected mixed etiologies (Management Guidelines)[EASL HCV]
- Because significant fibrosis may occur in patients with repeatedly normal ALT levels, assessment of disease severity should be performed regardless of ALT levels
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