Hepatitis C Virus Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Francesco Negro, MD (More Info)
  • Editors In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 10/30/20 (What's New)


  • The 5 key modes of HCV transmission include iatrogenic transmission, injection drug use, sexual transmission, mother-to-child transmission, and occupational exposure (Table 2)
  • Screening of all blood donors for anti-HCV antibodies and HCV RNA has virtually eliminated posttransfusion HCV infection[Schreiber 1996; Pomper 2003]
  • Iatrogenic transmission has become uncommon in developed countries with the introduction of strict hygiene and sanitation measures

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