Management of Hepatitis C Infection

  • Authors: Jordan J. Feld, MD, MPH; Hemant Shah, MD, MScCH HPTE (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 1/9/21 (What's New)


  • Glecaprevir is an NS3/NS4A protease inhibitor
  • Glecaprevir, coformulated with pibrentasvir, is approved by the FDA and the EMA for first-line treatment of patients infected with genotypes 1-6 HCV[FDA Glecaprevir Pibrentasvir; EMA Glecaprevir Pibrentasvir]
    • Some treatment-experienced patients are also eligible for treatment with this coformulation, depending on the type of agent previously used and HCV genotype

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