Hepatitis C Virus Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Francesco Negro, MD (More Info)
  • Editors In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 10/30/20 (What's New)


  • The rate of HCV transmission from mother to child is 5.8% among women who are HCV RNA positive, although the rate is higher, 10.8%, when the mother is HIV coinfected[Kushner 2018]
  • Guidelines from the AASLD recommend that all children born to women with HCV be tested for HCV infection with an antibody-based test at or after 18 months of age[AASLD-IDSA HCV]
  • HCV RNA assay can be considered as early as 2 months of age, but the optimal timing of such testing is unknown[AASLD-IDSA HCV]

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