Hepatitis B Management in Special Populations

  • Author: Alessandra Mangia, MD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 6/4/18 (What's New)


  • Treatment in the third trimester of pregnancy may lower risk of perinatal HBV transmission
  • Maternal viremia plays a significant role in perinatal transmission. Studies have reported increased risk of transmission with high levels of viremia (> 8 log10 copies/mL or ~ 7.3 log10 IU/mL)[Burk 1994; Xu 2009; van Zonneveld 2003]
  • AASLD guidance panel suggests antiviral therapy during third trimester to decrease risk of HBV perinatal transmission in HBsAg-positive pregnant women with HBV DNA > 200,000 IU/mL[AASLD HBV]

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