Management of Hepatitis C Infection

  • Authors: Jordan J. Feld, MD, MPH; Hemant Shah, MD, MScCH HPTE (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 1/9/21 (What's New)


  • Continuation of failing PI-based regimen promotes accumulation of additional, compensatory resistance mutations[Sarrazin 2010]
  • After PI stopped, PI-resistant HCV may decrease to baseline levels[Sarrazin 2010]
    • Rate of resistant virus “disappearance” depends on fitness of virus compared with wild-type virus

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