Virology and Immunology of Hepatitis Viruses

  • Authors: Esperance Anne Kreek Schaefer, MD, MPH; Raymond T. Chung, MD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/10/18 (What's New)


  • HEV is increasingly appreciated as a disease with a vast array of clinical manifestations from asymptomatic infection to fulminant hepatitis
  • Although generally considered a self-limited disease, some reports have described chronic HEV infection in immunosuppressed populations such as transplantation recipients, HIV infection, and cancer[Kamar 2008; Dalton 2009; Ollier 2009]
  • Exposure to HEV may be more prevalent in the US than previously considered, with 6% testing positive for anti-HEV in 2009-2010[Teshale 2015]
  • Replication and Immunopathogenesis

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