Hepatitis C Virus Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Francesco Negro, MD (More Info)
  • Editors In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 10/30/20 (What's New)


  • HCV is a major bloodborne human pathogen affecting approximately 1% of the global population[WHO 2017]
  • The most common route of transmission in developed countries is injection drug use, and the opioid epidemic has contributed to a steady rise in new cases since 2010
  • If untreated, most acute infections progress to chronic infection and liver disease

Action required