Hepatitis B Management in Special Populations

  • Author: Alessandra Mangia, MD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 6/4/18 (What's New)


  • HBV reactivation involves loss of HBV immune control in a patient with an inactive or a resolved HBV infection. Viral replication increases and liver damage occurs during or after immune reconstitution[Feld 2010]
  • Reactivation of HBV can result in liver failure or death[Roche 2011]
    • Occurs in 41% to 53% of HBsAg-positive, anti-HBc–positive patients receiving anticancer therapy and 12.3% receiving antirheumatic therapy[AASLD HBV]

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