Hepatitis A Virus and Hepatitis E Virus: Different Viruses With Similar Stories

  • Author: Kenneth E. Sherman, MD, PhD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 5/17/18 (What's New)


  • HAV infects approximately 1.4 million people worldwide each year, with higher prevalence in the developing world attributable to greater contamination of water and food[WHO 2014]

    • Whereas vaccination against HAV decreased the incidence of acute infection in the United States to 0.4 reported cases per 100,000 in 2015,[CDC Surveillance] this trend has since reversed with an ongoing outbreak among unvaccinated, high-risk populations[CDC Outbreak]

    • Since 2016, an ongoing outbreak among predominantly MSM in Europe has been associated with 11,212 cases of HAV infection, representing a 4-fold increase in annual rates observed for similar periods in 2012-2015[ECDPC]

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