Management of Hepatitis B Infection
Summary
- Some nucleos(t)ide analogues inhibit human mitochondrial DNA polymerases, which may result in lactic acidosis, neuropathy, and myopathy
- Most nucleos(t)ide analogues present limited risk of adverse events during the first years of therapy in patients with compensated liver disease
- Adverse event rates with lamivudine were similar to those seen with placebo in a randomized study[Dienstag 1999]
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