Hepatitis B Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Marc G. Ghany, MD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/2/18 (What's New)


  • HBV prevalence, routes of transmission, and genotype vary widely across geographic regions (Figure 1)
    • Areas with the highest prevalence (≥ 8%) are in west sub-Saharan Africa
    • Areas with high-intermediate prevalence (5% to 7%) include China, southeast Asia, and the remainder of sub-Saharan Africa
  • Hepatitis B Virus Epidemiologic Trends in the United States
      Geographical Distribution of Hepatitis B Virus Genotypes
        Clinical Significance of Hepatitis B Virus Genotype
          Effect of Immunization on Hepatitis B Virus Disease Burden

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