Hepatitis B Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Marc G. Ghany, MD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 7/2/18 (What's New)


  • HBsAg is the serologic hallmark of HBV infection
    • HBsAg usually appears in serum 1-10 weeks following exposure to HBV and approximately 4-6 weeks before onset of symptoms or elevation of serum aminotransferase levels[Krugman 1979; Holland 1975]
    • Resolution of infection is characterized by loss of HBsAg and detection of anti-HBs, which confers protection against HBV infection and usually persists for life

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