Hepatitis C Virus Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Francesco Negro, MD (More Info)
  • Editors In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 10/30/20 (What's New)


  • Primary infection with HCV is mostly asymptomatic and some patients may delay seeking medical consultation
    • As a result, the true incidence rate is underestimated[Armstrong 2000]
  • HCV is diagnosed via a documented seroconversion to anti-HCV in a person who was previously anti-HCV negative

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