Hepatitis A Virus and Hepatitis E Virus: Different Viruses With Similar Stories

  • Author: Kenneth E. Sherman, MD, PhD (More Info)
  • Editor In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 5/17/18 (What's New)


  • Both HAV and HEV are highly prevalent viruses that primarily replicate in the liver and cause acute hepatic injury
    • Both viruses appear to be important cofactors in the morbidity and mortality associated with other chronic liver diseases
  • Although members of different virus families, similarities in epidemiology, modes of transmission, and clinical presentation make it helpful to consider them together

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