Hepatitis C Virus Epidemiology, Pathogenesis, Diagnosis, and Natural History

  • Author: Francesco Negro, MD (More Info)
  • Editors In Chief: Stefan Zeuzem, MD
  • Last Reviewed: 10/30/20 (What's New)


  • Several extrahepatic manifestations (Table 3) associated with HCV infection may significantly affect its morbidity and mortality[Negro 2015]
    • The presence of a clinically significant extrahepatic manifestation may sometimes represent a sufficient indication for antiviral therapy
    • Availability of interferon-free regimens provides means of treating HCV-related autoimmune conditions with contraindications to interferon

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