Targeted Therapies

  • Author: Gail Wilkes, RNC, ANP-BC, MS, AOCN® (More Info)
  • Section Editor: Marlene SanFilippo, MSN, ARNP, FNP-C, AOCNP®
  • Editors In Chief: Dawn Camp-Sorrell, MSN, FNP, AOCN®; Rebecca Hawkins, MSN, ANP, AOCN®, ACHPN
  • Last Reviewed: 5/26/17 (What's New)


  • BRAF is a gene that makes a protein called BRAF (pronounced B-RAF) that is involved in sending signals inside cells and directing cell growth through the RAS/RAF/MEK/ERK pathway[Wilkes 2016]
  • BRAF inhibitors (Table 17, Table 18, Table 19) and MEK inhibitors (Table 20) are approved for malignant melanoma with a specific BRAF mutation called V600E
  • Key side effects of BRAF or MEK inhibitors for nurses to assess include new skin cancers or other dermatologic changes; serious visual changes; and hyperglycemia requiring medical management with dabrafenib

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