Targeted Therapies

  • Author: Gail Wilkes, RNC, ANP-BC, MS, AOCN® (More Info)
  • Section Editor: Marlene SanFilippo, MSN, ARNP, FNP-C, AOCNP®
  • Editors In Chief: Dawn Camp-Sorrell, MSN, FNP, AOCN®; Rebecca Hawkins, MSN, ANP, AOCN®, ACHPN
  • Last Reviewed: 7/9/18 (What's New)


  • BRAF is a gene that makes a protein called BRAF (pronounced B-RAF) that is involved in sending signals inside cells and directing cell growth through the RAS/RAF/MEK/ERK pathway[Wilkes 2018]
  • BRAF inhibitors (Tables 17-20) and MEK inhibitors (Tables 20-21) are approved for malignant melanoma with specific BRAF mutations called V600E or V600K
    • Combination of BRAF inhibitor encorafenib and MEK inhibitor binimetinib approved for advanced melanoma with BRAF V600E or V600K

Action required