Targeted Therapies

  • Author: Gail Wilkes, RNC, ANP-BC, MS, AOCN® (More Info)
  • Section Editor: Marlene SanFilippo, MSN, ARNP, FNP-C, AOCNP®
  • Editors In Chief: Dawn Camp-Sorrell, MSN, FNP, AOCN®; Rebecca Hawkins, MSN, ANP, AOCN®, ACHPN
  • Last Reviewed: 5/26/17 (What's New)

Summary

  • Uncontrolled cell division is due to an overexpression or mutation of EGFRs in many solid tumors
  • HER2 is part of the EGFR family and when overexpressed, can cause an aggressive type of breast cancer
  • TKIs that block the EGFR from inside the cell include afatinib, erlotinib, gefitinib, and lapatinib

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